Identification of transcripts associated with renal damage due to ureteral obstruction as candidate urinary biomarkers.

ABSTRACT: Renal obstruction is a common cause of renal failure in adults and children and is suspected when hydronephrosis is detected on imaging. Because not all cases of hydronephrosis are associated with renal damage, biomarkers are needed to guide intervention to relieve obstruction. We performed gene expression profiling on the kidneys from adult mice over a detailed time course after obstruction and compared these data with a neonatal model of bilateral high-grade obstruction induced by conditional deletion of the calcineurin β₁ gene. Having identified a set of 143 transcripts modulated in both adult and neonatal obstruction, we tested their expression in a model of short-term obstruction (1 day), where renal damage is transient and reversible, and long-term obstruction (5 days), wh

SUBMITTER: Wu B 

PROVIDER: S-EPMC6087789 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature