Time-resolved proteome profiling of normal lung development.

ABSTRACT: Biochemical networks mediating normal lung morphogenesis and function have important implications for ameliorating morbidity and mortality in premature infants. Although several transcript-level studies have examined normal lung development, corresponding protein-level analyses are lacking. Here we performed proteomics analysis of murine lungs from embryonic to early adult ages to identify the molecular networks mediating normal lung development. We identified 8,932 proteins, providing a deep and comprehensive view of the lung proteome. Analysis of the proteomics data revealed discrete modules and the underlying regulatory and signaling network modulating their expression during development. Our data support the cell proliferation that characterizes early lung development and highlight res

SUBMITTER: Moghieb A 

PROVIDER: S-EPMC6087896 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature