Integrative computational evaluation of genetic markers for Alzheimer's disease.

ABSTRACT: Recent studies have reported hundreds of genes linked to Alzheimer's Disease (AD). However, many of these candidate genes may be not identified in different studies when analyses were replicated. Moreover, results could be controversial. Here, we proposed a computational workflow to curate and evaluate AD related genes. The method integrates large scale literature knowledge data and gene expression data that were acquired from postmortem human brain regions (AD case/control: 31/32 and 22/8). Pathway Enrichment, Sub-Network Enrichment, and Gene-Gene Interaction analysis were conducted to study the pathogenic profile of the candidate genes, with 4 metrics proposed and validated for each gene. By using our approach, a scalable AD genetic database was developed, including AD related genes, pat

SUBMITTER: Li Z 

PROVIDER: S-EPMC6088103 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature