Rapid Detection of Shear-Induced Damage in Tissue-Engineered Cartilage Using Ultrasound.

ABSTRACT: Previous investigations have shown that tissue-engineered articular cartilage can be damaged under a combination of compression and sliding shear. In these cases, damage was identified in histological sections after a test was completed. This approach is limited, in that it does not identify when damage occurred. This especially limits the utility of an assay for evaluating damage when comparing modifications to a tissue-engineering protocol. In this investigation, the feasibility of using ultrasound (US) to detect damage as it occurs was investigated. US signals were acquired before, during, and after sliding shear, as were stereomicroscope images of the cartilage surface. Histology was used as the standard for showing if a sample was damaged. We showed that US reflections from the surfac

SUBMITTER: Mansour JM 

PROVIDER: S-EPMC6088252 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature