A smart all-in-one theranostic platform for CT imaging guided tumor microwave thermotherapy based on IL@ZrO₂ nanoparticles.

ABSTRACT: This study develops a simple hollow ZrO₂ nanostructure as a carrier to encapsulate ionic liquid (IL), which integrates the CT imaging function of the ZrO₂ shell and the microwave susceptibility function of the IL core. The simple nanostructure can be used as a multifunctional theranostic agent via combining diagnostic and therapeutic modalities into one "package". Based on the microwave susceptibility properties, the tumor inhibiting ratio can be over 90% in mice models after one-time thermal therapy upon microwave irradiation. In vitro and in vivo imaging results prove the potential of CT imaging application for real-time monitoring of biodistribution and metabolic processes, and assessing therapeutic outcomes. To our best knowledge, our study is

SUBMITTER: Shi H 

PROVIDER: S-EPMC6088435 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature