Determinants of the Nasal Microbiome: Pilot Study of Effects of Intranasal Medication Use.

ABSTRACT:

Introduction

A role for bacteria and other microbes has long been suspected in the chronic inflammatory sinonasal diseases. Recent studies utilizing culture-independent, sequence-based identification have demonstrated aberrant shifts in the sinus microbiota of chronic rhinosinusitis subjects, compared with ostensibly healthy controls. Examining how such microbiota shifts occur and the potential for physician-prescribed interventions to influence microbiota dynamics are the topics of the current article.

Methods

The nasal cavity microbiota of 5 subjects was serially examined over an 8-week period using pan-bacterial 16S rRNA gene sequencing. Four of the subjects were administered topical mometasone furoate spray, while 1 subject underwent a mupirocin decolonization procedure

SUBMITTER: Ramakrishnan VR 

PROVIDER: S-EPMC6088474 | biostudies-literature | 2018 Jan-Dec

REPOSITORIES: biostudies-literature