Association Between Low-Molecular-Weight Heparin and Risk of Bleeding Among Hemodialysis Patients: A Retrospective Cohort Study.

ABSTRACT:

Background

Low-molecular-weight heparins (LMWH) replaced unfractionated heparin (UFH) in multiple indications. Although LMWH efficacy in hemodialysis was demonstrated through multiple studies, their safety remains controversial. The potential bioaccumulation in patients undergoing chronic hemodialysis raised the question of bleeding risk among this population.

Objective

The aim of this study was to evaluate bleeding risk among patients with chronic hemodialysis receiving LMWH or UFH for the extracorporeal circuit anticoagulation.

Design

We conducted a retrospective cohort study on data extracted from the Régie de l'assurance maladie du Québec (RAMQ) and Med-Echo databases from January 2007 to March 2013.

Setting

Twenty-one hemodialysis centers in the pro

SUBMITTER: Lazrak HH 

PROVIDER: S-EPMC6088481 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature