Impaired cognitive plasticity and goal-directed control in adolescent obsessive-compulsive disorder.

ABSTRACT:

Background

Youths with obsessive-compulsive disorder (OCD) experience severe distress and impaired functioning at school and at home. Critical cognitive domains for daily functioning and academic success are learning, memory, cognitive flexibility and goal-directed behavioural control. Performance in these important domains among teenagers with OCD was therefore investigated in this study.

Methods

A total of 36 youths with OCD and 36 healthy comparison subjects completed two memory tasks: Pattern Recognition Memory (PRM) and Paired Associates Learning (PAL); as well as the Intra-Extra Dimensional Set Shift (IED) task to quantitatively gauge learning as well as cognitive flexibility. A subset of 30 participants of each group also completed a Differential-Outcome Effect (DOE)

SUBMITTER: Gottwald J 

PROVIDER: S-EPMC6088771 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature