The Corneal Basement Membranes and Stromal Fibrosis.

ABSTRACT:

Purpose

The purpose of this review was to provide detailed insights into the pathophysiology of myofibroblast-mediated fibrosis (scarring or late haze) after corneal injury, surgery, or infection.

Method

Literature review.

Results

The epithelium and epithelial basement membrane (EBM) and/or endothelium and Descemet's basement membrane (BM) are commonly disrupted after corneal injuries, surgeries, and infections. Regeneration of these critical regulatory structures relies on the coordinated production of BM components, including laminins, nidogens, perlecan, and collagen type IV by epithelial, endothelial, and keratocyte cells. Whether a cornea, or an area in the cornea, heals with transparency or fibrosis may be determined by whether there is injury to one or both cor

SUBMITTER: Medeiros CS 

PROVIDER: S-EPMC6088801 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature