Towards the complex dependence of MTR_asym on T_1w in amide proton transfer (APT) imaging.

ABSTRACT: Amide proton transfer (APT) imaging is a variation of chemical exchange saturation transfer MRI that has shown promise in diagnosing tumors, ischemic stroke, multiple sclerosis, traumatic brain injury, etc. Specific quantification of the APT effect is crucial for the interpretation of APT contrast in pathologies. Conventionally, magnetization transfer ratio with asymmetric analysis (MTR_asym ) has been used to quantify the APT effect. However, some studies indicate that MTR_asym is contaminated by water longitudinal relaxation time (T_1w ), and thus it is necessary to normalize T_1w in MTR_asym to obtain specific quantification of the APT effect. So far, whether to use MTR_asym or the T_1w -normalized MTR_asym

SUBMITTER: Zu Z 

PROVIDER: S-EPMC6089235 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature