Pleiotropic effects of n-6 and n-3 fatty acid-related genetic variants on circulating hemostatic variables.

ABSTRACT:

Introduction

Data from epidemiological studies and clinical trials suggest an influence of dietary and circulating polyunsaturated fatty acids (PUFAs) on the hemostasis profile. Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) related to plasma PUFAs levels. We aimed to investigate whether the SNPs related to plasma PUFAs levels were also associated with plasma levels of hemostatic variables.

Materials and methods

We tested the associations between 9 PUFA-related SNPs and 6 hemostatic variables in 9035 European Americans (EAs) and 2702 African Americans (AAs) in the Atherosclerosis Risk in Communities (ARIC) Study. We then conducted a replication study by looking-up our novel observed associations in three published GWAS for hemos

SUBMITTER: Weng LC 

PROVIDER: S-EPMC6089352 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature