Brain Structure and Response to Emotional Stimuli as Related to Gut Microbial Profiles in Healthy Women.

ABSTRACT:

Objective

Brain-gut-microbiota interactions may play an important role in human health and behavior. Although rodent models have demonstrated effects of the gut microbiota on emotional, nociceptive, and social behaviors, there is little translational human evidence to date. In this study, we identify brain and behavioral characteristics of healthy women clustered by gut microbiota profiles.

Methods

Forty women supplied fecal samples for 16S rRNA profiling. Microbial clusters were identified using Partitioning Around Medoids. Functional magnetic resonance imaging was acquired. Microbiota-based group differences were analyzed in response to affective images. Structural and diffusion tensor imaging provided gray matter metrics (volume, cortical thickness, mean curvature, surfac

SUBMITTER: Tillisch K 

PROVIDER: S-EPMC6089374 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature