Developmental origin and morphogenesis of the diaphragm, an essential mammalian muscle.

ABSTRACT: The diaphragm is a mammalian skeletal muscle essential for respiration and for separating the thoracic and abdominal cavities. Development of the diaphragm requires the coordinated development of muscle, muscle connective tissue, tendon, nerves, and vasculature that derive from different embryonic sources. However, defects in diaphragm development are common and the cause of an often deadly birth defect, Congenital Diaphragmatic Hernia (CDH). Here we comprehensively describe the normal developmental origin and complex spatial-temporal relationship between the different developing tissues to form a functional diaphragm using a developmental series of mouse embryos genetically and immunofluorescently labeled and analyzed in whole mount. We find that the earliest developmental events are the

SUBMITTER: Sefton EM 

PROVIDER: S-EPMC6089379 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature