Association of weight gain and fifteen adipokines with declining beta-cell function in Mexican Americans.

ABSTRACT: Obesity and adipokines are associated with development of type 2 diabetes. However, limited longitudinal studies have examined their roles on declining β-cell function over time. This report assessed three adiposity measures (BMI, percent body fat, trunk fat), insulin resistance, and fifteen adipokines in relationship to longitudinal change in β-cell function measured by disposition index (DI) from frequently-sampled-intravenous-glucose-tolerance testing. The results showed that three factors were significantly and independently associated with rate of change in DI over time: rate of change in BMI (negative), rate of change in IL-6 (negative), and baseline adiponectin (positive). The association was the strongest for changing BMI and was largely explained by changing insulin resistance; th

SUBMITTER: Xiang AH 

PROVIDER: S-EPMC6089433 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature