Statin use associated with lower risk of epilepsy after intracranial haemorrhage: A population-based cohort study.

ABSTRACT:

Aims

To examine the association between statin use before and after intracranial haemorrhage (ICH) and the risk of poststroke epilepsy (PSE).

Methods

Patients with new-onset ICH between 2004 and 2012 were identified from the Taiwan National Health Insurance Research Database. The main outcome was the occurrence of epilepsy after stroke. Multivariable Cox regression modelling was used to estimate the association between statin use and the risk of PSE, with poststroke medication exposures being treated as time-dependent variables.

Results

A total of 7435 patients with ICH were enrolled with a median follow-up of 17.6 months. Within the study cohort, 709 patients developed PSE. Poststroke, but not prestroke, stain use was associated with a reduced risk of PSE (adjusted h

SUBMITTER: Lin HW 

PROVIDER: S-EPMC6089806 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature