Use of antipsychotics and risk of breast cancer: a Danish nationwide case-control study.

ABSTRACT:

Aims

Some antipsychotics increase prolactin levels, which might increase the risk of breast cancer. Existing evidence is conflicting and based on sparse data, especially for the increasingly used second-generation antipsychotics. We conducted a nationwide case-control study of the association between antipsychotic use and incident breast cancer.

Methods

From the Danish Cancer Registry, we identified women with a first-time diagnosis of breast cancer 2000-2015 (n = 60 360). For each case, we age-matched 10 female population controls. Using conditional logistic regression, we calculated odds ratios (ORs) for breast cancer associated with use of antipsychotics. We stratified antipsychotics by first- and second-generation status and by ability to induce elevation of prolactin.

SUBMITTER: Pottegard A 

PROVIDER: S-EPMC6089812 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature