Pharmacokinetics of cefuroxime in infants and neonates undergoing cardiac surgery.

ABSTRACT:

Aims

Very little data exist regarding the effect of cardiopulmonary bypass (CPB) on cefuroxime (CXM) pharmacokinetics in children less than one year of age.

Methods

50 mg kg^-1 CXM i.v. after induction were followed by 75 mg kg^-1 into the CPB circuit. In 42 patients undergoing cardiac surgery, 15-20 samples were obtained between 5 and 360 min after the first dose. Total CXM concentrations were measured by high-performance liquid chromatography and a pharmacokinetic/pharmacodynamic (PK/PD) modelling was performed.

Results

Using a fixed protein binding of 15.6% for CXM, peak plasma concentrations of unbound CXM were 229 ± 52 μg ml^-1 after the first bolus and 341 ± 86 μg ml^-1 on CPB. Nadir concentrations before CPB were 69 ± 20 

SUBMITTER: Gertler R 

PROVIDER: S-EPMC6089814 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature