Gastrointestinal bleeding risk of selective serotonin reuptake inhibitors by level of kidney function: A population-based cohort study.

ABSTRACT:

Aim

To estimate the risk of gastrointestinal (GI) bleeding associated with serotonin reuptake inhibitors (SSRIs) by level of kidney function.

Methods

We conducted a cohort study using the Clinical Practice Research Datalink linked to Hospital Episode Statistics. We identified patients with chronic kidney disease (CKD; estimated glomerular filtration rate <60 ml min^-1  1.73 m^-2 for ≥3 months), and a comparison group of patients without it. Patients with CKD were further classified as stage 3a (eGFR 45-59 ml min^-1  1.73 m^-2 ), 3b (30-44 ml min^-1  1.73 m^-2 ) and 4/5 (<30 ml min^-1  1.73 m^-2 ). We excluded prevalent SSRI users at cohort entry. Exposure was time-dependent SSRI prescription and

SUBMITTER: Iwagami M 

PROVIDER: S-EPMC6089824 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature