Physiologically-based pharmacokinetic model of vaginally administered dapivirine ring and film formulations.

ABSTRACT:

Aims

A physiologically-based pharmacokinetic (PBPK) model of the vaginal space was developed with the aim of predicting concentrations in the vaginal and cervical space. These predictions can be used to optimize the probability of success of vaginally administered dapivirine (DPV) for HIV prevention. We focus on vaginal delivery using either a ring or film.

Methods

A PBPK model describing the physiological structure of the vaginal tissue and fluid was defined mathematically and implemented in MATLAB. Literature reviews provided estimates for relevant physiological and physiochemical parameters. Drug concentration-time profiles were simulated in luminal fluids, vaginal tissue and plasma after administration of ring or film. Patient data were extracted from published clinical

SUBMITTER: Kay K 

PROVIDER: S-EPMC6089833 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature