The Reissner Fiber in the Cerebrospinal Fluid Controls Morphogenesis of the Body Axis.

ABSTRACT: Organ development depends on the integration of coordinated long-range communication between cells. The cerebrospinal fluid composition and flow properties regulate several aspects of central nervous system development, including progenitor proliferation, neurogenesis, and migration [1-3]. One understudied component of the cerebrospinal fluid, described over a century ago in vertebrates, is the Reissner fiber. This extracellular thread forming early in development results from the assembly of the SCO-spondin protein in the third and fourth brain ventricles and central canal of the spinal cord [4]. Up to now, the function of the Reissner fiber has remained elusive, partly due to the lack of genetic invalidation models [4]. Here, by mutating the scospondin gene, we demonstrate that the Reiss

SUBMITTER: Cantaut-Belarif Y 

PROVIDER: S-EPMC6089837 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature