Comparative toxicity of synchrotron and conventional radiation therapy based on total and partial body irradiation in a murine model.

ABSTRACT: Synchrotron radiation can facilitate novel radiation therapy modalities such as microbeam radiation therapy (MRT) and high dose-rate synchrotron broad-beam radiation therapy (SBBR). Both of these modalities have unique physical properties that could be exploited for an improved therapeutic effect. While pre-clinical studies report promising normal tissue sparing phenomena, systematic toxicity data are still required. Our objective was to characterise the toxicity of SBBR and MRT and to calculate equivalent doses of conventional radiation therapy (CRT). A dose-escalation study was performed on C57BLJ/6 mice using total body and partial body irradiations. Dose-response curves and TD₅₀ values were subsequently calculated using PROBIT analysis. For SBBR at dose-rates of 37 to 41 Gy/

SUBMITTER: Smyth LML 

PROVIDER: S-EPMC6089899 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature