Elicitors Derived from Hazel (Corylus avellana L.) Cell Suspension Culture Enhance Growth and Paclitaxel Production of Epicoccum nigrum.

ABSTRACT: The microbial fermentation is considered as the potential source for large-scale production of paclitaxel. Since co-cultivation/mixed fermentation strategy has been reported as a yield enhancement strategy for paclitaxel production, investigation of fungal endophyte response to plant culture medium, plant cell extract (CE) and medium filtrate (MF) of plant cell suspension culture in terms of growth and paclitaxel production is interesting. In this study, 35 endophytic fungi were isolated from Taxus baccata and Corylus avellana grown in Iran. The analysis of high-performance liquid chromatography and mass spectrometry showed that one isolate (YEF₂) produced paclitaxel. The isolate YEF₂ was identified as Epicoccum nigrum by sequencing of ITS1-5.8S-ITS2 rDNA region and a

SUBMITTER: Salehi M 

PROVIDER: S-EPMC6089963 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature