Snake Venom Extracellular vesicles (SVEVs) reveal wide molecular and functional proteome diversity.

ABSTRACT: Proteins constitute almost 95% of snake venom's dry weight and are produced and released by venom glands in a solubilized form during a snake bite. These proteins are responsible for inducing several pharmacological effects aiming to immobilize and initiate the pre-digestion of the prey. This study shows that proteins can be secreted and confined in snake venom extracellular vesicles (SVEVs) presenting a size distribution between 50 nm and 500 nm. SVEVs isolated from lyophilized venoms collected from four different species of snakes (Agkistrodon contortrix contortrix, Crotalus atrox, Crotalus viridis and Crotalus cerberus oreganus) were analyzed by mass spectrometry-based proteomic, which allowed the identification of proteins belonging to eight main functional protein classes such as SVMP

SUBMITTER: Carregari VC 

PROVIDER: S-EPMC6089973 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature