Mitochondrial ribosomal proteins involved in tellurite resistance in yeast Saccharomyces cerevisiae.

ABSTRACT: A considerable body of evidence links together mitochondrial dysfunctions, toxic action of metalloid oxyanions, and system and neurodegenerative disorders. In this study we have used the model yeast Saccharomyces cerevisiae to investigate the genetic determinants associated with tellurite resistance/sensitivity. Nitrosoguanidine-induced K₂TeO₃-resistant mutants were isolated, and one of these mutants, named Sc57-Te₅^R, was characterized. Both random spore analysis and tetrad analysis and growth of heterozygous (Te^S/Te₅^R) diploid from Sc57-Te₅^R mutant revealed that nuclear and recessive mutation(s) was responsible for the resistance. To get insight into the mechanisms responsible for K₂

SUBMITTER: Pontieri P 

PROVIDER: S-EPMC6089990 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature