Limonoids from seeds of Azadirachta indica A. Juss. and their cytotoxic activity.

ABSTRACT: Four new limonoid-type nortriterpenoids, 1-detigloyl-1-O-methacryloylsalannin (1), 28-deoxo-2,3-dihydronimbolide (2), 12-acetoxy-3-O-acetyl-7-O-tigloylvilasinin (3) and 12-acetoxy-3-O-acetyl-7-O-methacryloylvilasinin (4), along with five known ones, were isolated from seeds of Azadirachta indica A. Juss. Their structures were elucidated by various spectroscopic methods, including UV, IR, MS, NMR, X-ray crystallography, quantum chemical calculation, as well as by comparison of their spectroscopic data with those reported. In the in vitro cytotoxic assay, 2 showed inhibitory activity against human breast cancer MDA-MB-231 cell line with IC₅₀ value of 7.68±1.74 μmol/L, and 5 inhibited growth

SUBMITTER: Chen J 

PROVIDER: S-EPMC6090013 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature