Assessing and Interpreting the Within-Body Biogeography of Human Microbiome Diversity.

ABSTRACT: A human body hosts a relatively independent microbiome including five major regional biomes (i.e., airway, oral, gut, skin, and urogenital). Each of them may possess different regional characteristics with important implications to our health and diseases (i.e., so-termed microbiome associated diseases). Nevertheless, these regional microbiomes are connected with each other through diffusions and migrations. Here, we investigate the within-body (intra-individual) distribution feature of microbiome diversity via diversity area relationship (DAR) modeling, which, to the best of our knowledge, has not been systematically studied previously. We utilized the Hill numbers for measuring alpha and beta-diversities and built 1,200 within-body DAR models with to date the most comprehensive human mic

SUBMITTER: Ma Z 

PROVIDER: S-EPMC6090070 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature