Comprehensive integrated analysis of gene expression datasets identifies key anti-cancer targets in different stages of breast cancer.

ABSTRACT: Breast cancer is one of the primary threats to women's health worldwide. However, the molecular mechanisms underlying the development of breast cancer remain to be fully elucidated. The present study aimed to investigate specific target gene expression profiles in breast cancer tissues in general and in different breast cancer stages, as well as to explore their functions in tumor development. For integrated analysis, a total of 5 gene expression profiling datasets for 3 different stages of breast cancer (stages I-III) were downloaded from the Gene Expression Omnibus of the National Center for Biotechnology Information. Pre-processing of these datasets was performed using the Robust Multi-array Average algorithm and global renormalization was performed for all studies. Differentially expre

SUBMITTER: Gong MT 

PROVIDER: S-EPMC6090421 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature