Single-Molecule Clocks Controlled by Serial Chemical Reactions.

ABSTRACT: Chemical clocks usually achieve well-defined temporal delays through concentration thresholding coupled to the production, degradation, activation, or inhibition of downstream effectors. In this way, the stochastic dynamics of many individual molecules yield essentially deterministic bulk behavior through ensemble averaging. As a result, their temporal evolution is governed by ensemble dynamics rather than by the behavior of an individual molecule or complex. Here, we present a general approach for the design of single-molecule clocks that permits quasi-deterministic control over the lifetime of single molecular interactions without any external synchronization. By coupling the dissociation of a bimolecular complex to a series of irreversible chemical steps, we interpose a well-defined tim

SUBMITTER: Johnson-Buck A 

PROVIDER: S-EPMC6090534 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature