Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides.

ABSTRACT: Tissue-specific autoimmunity occurs when selected antigens presented by susceptible alleles of the major histocompatibility complex are recognized by T cells. However, the reason why certain specific self-antigens dominate the response and are indispensable for triggering autoreactivity is unclear. Spontaneous presentation of insulin is essential for initiating autoimmune type 1 diabetes in non-obese diabetic mice^1,2. A major set of pathogenic CD4 T cells specifically recognizes the 12-20 segment of the insulin B-chain (B:12-20), an epitope that is generated from direct presentation of insulin peptides by antigen-presenting cells^3,4. These T cells do not respond to antigen-presenting cells that have taken up insulin that, after processing, leads to presentation of a d

SUBMITTER: Wan X 

PROVIDER: S-EPMC6090537 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature