Mapping dynamic histone modification patterns during arsenic-induced malignant transformation of human bladder cells.

ABSTRACT: Arsenic is a known potent risk factor for bladder cancer. Increasing evidence suggests that epigenetic alterations, e.g., DNA methylation and histones posttranslational modifications (PTMs), contribute to arsenic carcinogenesis. Our previous studies have demonstrated that exposure of human urothelial cells (UROtsa cells) to monomethylarsonous acid (MMA^III), one of arsenic active metabolites, changes the histone acetylation marks across the genome that are correlated with MMA^III-induced UROtsa cell malignant transformation. In the current study, we employed a high-resolution and high-throughput liquid chromatography tandem mass spectrometry (LC-MS/MS) to identify and quantitatively measure various PTM patterns during the MMA^III-induced malignant transformati

SUBMITTER: Ge Y 

PROVIDER: S-EPMC6090552 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature