Ontology highlight
ABSTRACT:
SUBMITTER: Ayata P
PROVIDER: S-EPMC6090564 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature neuroscience 20180723 8
The rapid elimination of dying neurons and nonfunctional synapses in the brain is carried out by microglia, the resident myeloid cells of the brain. Here we show that microglia clearance activity in the adult brain is regionally regulated and depends on the rate of neuronal attrition. Cerebellar, but not striatal or cortical, microglia exhibited high levels of basal clearance activity, which correlated with an elevated degree of cerebellar neuronal attrition. Exposing forebrain microglia to apop ...[more]