MicroRNA-524 promotes cell proliferation by down-regulating PTEN expression in osteosarcoma.

ABSTRACT:

Background

Increasing numbers of studies have examined the correlation between specific miRNAs and tumours to enable their diagnosis and treatment. However, there are few reports regarding the concrete role and mechanism of miRNA in osteosarcoma.

Methods

The expression of miR-524 in osteosarcoma tissues and cell lines was examined by qRT-PCR. The cell proliferation was examined using CCK-8 in vitro. A series of bioinformatics and molecular biology techniques were adopted to investigate the regulatory relationship between miR-524 and target genes in osteosarcoma.

Results

The results showed that the miRNA with the most significant differential expression in osteosarcoma was miR-524, which was significantly up-regulated in both osteosarcoma tissues and cell lines. MiR-52

SUBMITTER: Zhuang M 

PROVIDER: S-EPMC6090628 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature