Regulatory role of heme oxygenase-1 in silica-induced lung injury.

ABSTRACT:

Background

Silicosis, a progressive inflammatory lung disease attributed mainly to occupational exposure to silica dust, shows loss of lung function even after cessation of exposure. In addition to conventional evaluation methods such as chest X-ray, computed tomography, and spirometry, we identified heme oxygenase (HO)-1, an inducible antioxidant, as a potential biomarker to identify at-risk patients. We found that HO-1 was critical in attenuating the disease progression of silicosis; however, the key signaling pathway has not yet been elucidated. Here, we report the critical pathway after silica exposure, focusing on the role of silica-derived reactive oxygen species (ROS) signaling and its attenuation, which is mediated by HO-1 induction, in vivo and in vitro.

Methods

Nor

SUBMITTER: Nakashima K 

PROVIDER: S-EPMC6090697 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature