Altered miRNA profile in testis of post-cryptorchidopexy patients with non-obstructive azoospermia.

ABSTRACT:

Background

Cryptorchidism is one of the most common causes of non-obstructive azoospermia (NOA) leading to male infertility. Despite various medical approaches been utilised, many patients still suffer from infertility. MicroRNAs (miRNAs) play vital roles in the progress of spermatogenesis; however, little is known about the miRNA expression profile in the testes. Therefore, the miRNA profile was assessed in the testis of post-cryptorchidopexy patients.

Methods

Three post-cryptorchidopexy testicular tissue samples from patients aged 23, 26 and 28 years old and three testis tissues from patients with obstructive azoospermia (controls) aged 24, 25 and 36 years old were used in this study. Next-generation sequencing (NGS) was used to perform the miRNA expression profiling. Quan

SUBMITTER: Tang D 

PROVIDER: S-EPMC6090726 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature