Phylogenetic analysis of the wild-type strains of canine distemper virus circulating in the United States.

ABSTRACT:

Background

Canine distemper (CD) is a highly contagious, systemic, viral disease of dogs seen worldwide. Despite intensive vaccination in developed countries, recent reports suggest both the re-emergence and increased activity of Canine distemper virus (CDV) worldwide, including the United States. CDV is an RNA virus of the genus Morbillivirus within the family Paramyxoviridae. Viral genomic RNA encodes six structural proteins. Of the six structural proteins, the hemagglutinin (H) gene has the greatest genetic variation and is therefore a suitable target for molecular epidemiological studies. The majority of neutralizing epitopes are found on the H protein, making this gene also important for evaluation of changes over time that may result in antigenic differences among strains. Th

SUBMITTER: Anis E 

PROVIDER: S-EPMC6090796 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature