EQTL discovery and their association with severe equine asthma in European Warmblood horses.

ABSTRACT:

Background

Severe equine asthma, also known as recurrent airway obstruction (RAO), is a debilitating, performance limiting, obstructive respiratory condition in horses that is phenotypically similar to human asthma. Past genome wide association studies (GWAS) have not discovered coding variants associated with RAO, leading to the hypothesis that causative variant(s) underlying the signals are likely non-coding, regulatory variant(s). Regions of the genome containing variants that influence the number of expressed RNA molecules are expression quantitative trait loci (eQTLs). Variation associated with RAO that also regulates a gene's expression in a disease relevant tissue could help identify candidate genes that influence RAO if that gene's expression is also associated with RAO dis

SUBMITTER: Mason VC 

PROVIDER: S-EPMC6090848 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature