Virulence-related comparative transcriptomics of infectious and non-infectious chlamydial particles.

ABSTRACT:

Background

Members of the phylum Chlamydiae are obligate intracellular pathogens of humans and animals and have a serious impact on host health. They comprise several zoonotic species with varying disease outcomes and prevalence. To investigate differences in virulence, we focused on Chlamydia psittaci, C. abortus and Waddlia chondrophila. Most threatening is C. psittaci, which frequently infects humans and causes psittacosis associated with severe pneumonia. The closest relative of C. psittaci is C. abortus, which shares the vast majority of genes but less frequently infects humans, and causes stillbirth and sepsis. W. chondrophila is more distantly related, and occasional human infections are associated with respiratory diseases or miscarriage. One possible explanation for differ

SUBMITTER: Beder T 

PROVIDER: S-EPMC6090853 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature