A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk.

ABSTRACT:

Background

Helicobacter pylori are stomach-dwelling bacteria that are present in about 50% of the global population. Infection is asymptomatic in most cases, but it has been associated with gastritis, gastric ulcers and gastric cancer. Epidemiological evidence shows that progression to cancer depends upon the host and pathogen factors, but questions remain about why cancer phenotypes develop in a minority of infected people. Here, we use comparative genomics approaches to understand how genetic variation amongst bacterial strains influences disease progression.

Results

We performed a genome-wide association study (GWAS) on 173 H. pylori isolates from the European population (hpEurope) with known disease aetiology, including 49 from individuals with gastric cancer. We identif

SUBMITTER: Berthenet E 

PROVIDER: S-EPMC6090961 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature