Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging.

ABSTRACT:

Background

Mammals display a wide range of variation in their lifespan. Investigating the molecular networks that distinguish long- from short-lived species has proven useful to identify determinants of longevity. Here, we compared the livers of young and old long-lived naked mole-rats (NMRs) and the phylogenetically closely related, shorter-lived, guinea pigs using an integrated omics approach.

Results

We found that NMR livers display a unique expression pattern of mitochondrial proteins that results in distinct metabolic features of their mitochondria. For instance, we observed a generally reduced respiration rate associated with lower protein levels of respiratory chain components, particularly complex I, and increased capacity to utilize fatty acids. Interestingly, we sh

SUBMITTER: Heinze I 

PROVIDER: S-EPMC6090990 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature