Esmolol infusion in patients with septic shock and tachycardia: a prospective, single-arm, feasibility study.

ABSTRACT:

Background

High adrenergic tone appears to be associated with mortality in septic shock, while adrenergic antagonism may improve survival. In preparation for a randomized trial, we conducted a prospective, single-arm pilot study of esmolol infusion for patients with septic shock and tachycardia that persists after adequate volume expansion.

Methods

From April 2016 to March 2017, we enrolled patients admitted to an intensive care unit with sepsis who were receiving vasopressor infusion and were tachycardic despite adequate volume expansion. All patients received a continuous intravenous infusion of esmolol, targeted to heart rate 80-90/min, while receiving vasopressors. The feasibility outcomes were proportion of eligible patients consented, compliance with pre-infusion safet

SUBMITTER: Brown SM 

PROVIDER: S-EPMC6091011 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature