A metagenomic study of the gut microbiome in Behcet's disease.

ABSTRACT:

Background

Behcet's disease (BD) is a recalcitrant, multisystemic inflammatory disease that can lead to irreversible blindness. Microbial agents have been considered to contribute to the pathogenesis of this disease, but the underlying mechanisms remain unclear. In this study, we investigated the association of gut microbiome composition with BD as well as its possible roles in the development of this disease.

Methods

Fecal and saliva samples were collected from 32 active BD patients and 74 healthy controls. DNA extracted from fecal samples was subjected to metagenomic analysis, whereas DNA extracted from saliva samples was subjected to 16S rRNA gene sequencing analysis. The results were used to compare the composition and biological function of the microbiome between patien

SUBMITTER: Ye Z 

PROVIDER: S-EPMC6091101 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature