Platelet storage duration and its clinical and transfusion outcomes: a systematic review.

ABSTRACT:

Background

Platelets (PLTs) are usually stored for up to 5 days prior to transfusion, although in some blood services the storage period is extended to 7 days. During storage, changes occur in both PLT and storage medium, which may lead to PLT activation and dysfunction. The clinical significance of these changes remains uncertain.

Methods

We performed a systematic review to assess the association between PLT storage time and clinical or transfusion outcomes in patients receiving allogeneic PLT transfusion. We searched studies published in English between January 2000 and July 2017 identified from MEDLINE, Embase, PubMed and the Cochrane Libraries.

Results

Of the 18 studies identified, five included 4719 critically ill patients (trauma, post-cardiac surgery and a hete

SUBMITTER: Aubron C 

PROVIDER: S-EPMC6091146 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature