Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines.

ABSTRACT:

Background

Sirtuin 2 (SIRT2) is a member of the sirtuin family, nicotinamide adenine dinucleotide⁺-dependent deacylases, which participates in modulation of cell cycle control, neurodegeneration, and tumorigenesis. SIRT2 expression increases in acute myeloid leukemia blasts. Downregulation of SIRT2 using siRNA causes apoptosis of HeLa cells. Therefore, selective inhibitors of SIRT2 are candidate therapeutic agents for cancer. Adult T-cell leukemia/lymphoma (ATL) is a T-cell malignancy that has a poor prognosis and develops after long-term infection with human T-cell leukemia virus (HTLV)-1. Sirtuin 1 inhibition has been shown to induce apoptosis and autophagy in HTLV-1-infected cell lines, whereas the effects of SIRT2 inhibition alone have not been elucidated.

Methods

SUBMITTER: Kozako T 

PROVIDER: S-EPMC6091197 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature