Pathway Network Analysis of Complex Diseases Based on Multiple Biological Networks.

ABSTRACT: Biological pathways play important roles in the development of complex diseases, such as cancers, which are multifactorial complex diseases that are usually caused by multiple disorders gene mutations or pathway. It has become one of the most important issues to analyze pathways combining multiple types of high-throughput data, such as genomics and proteomics, to understand the mechanisms of complex diseases. In this paper, we propose a method for constructing the pathway network of gene phenotype and find out disease pathogenesis pathways through the analysis of the constructed network. The specific process of constructing the network includes, firstly, similarity calculation between genes expressing data combined with phenotypic mutual information and GO ontology information, secondly, c

SUBMITTER: Zheng F 

PROVIDER: S-EPMC6091292 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature