T₁-T₂ molecular magnetic resonance imaging of renal carcinoma cells based on nano-contrast agents.

ABSTRACT:

Background

The development of T₁-T₂ dual contrast agent (CA) favors the visualization of the lesion in a more accurate and reliable manner by magnetic resonance imaging (MRI). The relaxivity and the interference between T₁ and T₂ CA are the main concerns for their design.

Methods

In this work, we constructed an Fe₃O₄@mSiO₂/PDDA/BSA-Gd₂O₃ nanocomplex where BSA-Gd₂O₃ NPs and Fe₃O₄ NPs were chosen as T₁ and T₂ MRI CAs and a 20 nm mesoporous silica (mSiO₂) nanoshell was introduced to reduce the interference between them. We performed transmis sion electron microscopy, X-ray powder diffraction, UV-vis absor

SUBMITTER: Li J 

PROVIDER: S-EPMC6091481 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature