Cyclic RGD-conjugated Pluronic^® blending system for active, targeted drug delivery.

ABSTRACT:

Background

Blending micellar systems of different types of polymers has been proposed as an efficient approach for tailor-made drug formulations. The lamellar structure of hydrophobic polymers may provide a high drug loading capacity, and hydrophilic polymers may provide good colloidal stability.

Methods

In this study, the anticancer model drug docetaxel was loaded onto a nanosized blending micellar system with two pluronics (L121/F127). To achieve increased antitumor activity, the cyclic arginine-glycine-aspartic acid tripeptide (cRGD) as an active tumor targeting ligand was conjugated to the blending system.

Results

The docetaxel-loaded Pluronic blending system exhibited a higher drug loading capacity than that of F127 and showed high colloidal stability with a sphe

SUBMITTER: Lim C 

PROVIDER: S-EPMC6091488 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature