Cognitive function in 1736 participants in NINDS Exploratory Trials in PD Long-term Study-1.

ABSTRACT:

Introduction

Clinical cohort studies suggest that mild cognitive impairment (MCI) is common in early Parkinson's disease (PD). The objectives of this paper were to describe cognitive function in a large clinical trial of early treated PD patients at baseline and over time using two brief cognitive screening tests.

Methods

In total 1741 participants were enrolled in the NINDS Exploratory Trials in Parkinson's disease (NET-PD) Long-term Study-1 (LS-1). The Symbol Digit Modalities Test (SDMT) was collected annually. The SCales for Outcomes in PArkinson's disease-COGnition (SCOPA-COG) was collected at baseline and at year 5. The trial was stopped early based on a planned interim analysis after half the cohort completed 5 years of follow-up. The median length of follow-up was 4 y

SUBMITTER: Wills AA 

PROVIDER: S-EPMC6091572 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature