Impact of missing individual patient data on 18 meta-analyses of randomised trials in oncology: Gustave Roussy experience.

ABSTRACT:

Objective

To compare the characteristics, quality and treatment effects of randomised clinical trials (RCTs) by individual patient data (IPD) availability, in trials eligible for 18 IPD meta-analyses (MA).

Design

Trial characteristics, risk of bias (RoB) and hazard ratio (HR) for overall survival were extracted from IPD-MA publications and/or RCTs publications. Data for the RoB assessment were extracted for a subset of 73 RCTs. Two investigators blinded to whether IPD was available or not evaluated the RoB for these trials. Treatment effects were compared using ratios of global HRs (RHRs) of IPD-unavailable trials and IPD-available trials. RHR were pooled using a fixed-effect model.

Data sources

We examined the IPD availability for each trial eligible for each IPD-MA;

SUBMITTER: Fayard F 

PROVIDER: S-EPMC6091903 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature