Oxytocin receptor is regulated by Peg3.
Ontology highlight
ABSTRACT:
SUBMITTER: Frey WD
PROVIDER: S-EPMC6091971 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Oxytocin receptor is regulated by Peg3.
Frey Wesley D WD Sharma Kaustubh K Cain Terri L TL Nishimori Katsuhiko K Teruyama Ryoichi R Kim Joomyeong J
PloS one 20180814 8
Mouse Peg3 encodes a DNA-binding protein involved in the milk letdown process. In the current study, we tested whether PEG3 controls the expression of the oxytocin receptor gene. According to the results, PEG3 directly binds to a genomic region within the 3rd exon of Oxtr, which contains a DNA-binding motif for PEG3. In nursing female mice, removal of PEG3 resulted in the increased expression of Oxtr in mammary epithelial cells and also in the hypothalamus. This suggests a repressor role of PEG3 ...[more]
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