Synovial Fluid Metabolites Differentiate between Septic and Nonseptic Joint Pathologies.

ABSTRACT: Osteoarthritis (OA), osteochondrosis (OC), and synovial sepsis in horses cause loss of function and pain. Reliable biomarkers are required to achieve accurate and rapid diagnosis, with synovial fluid (SF) holding a unique source of biochemical information. Nuclear magnetic resonance (NMR) spectroscopy allows global metabolite analysis of a small volume of SF, with minimal sample preprocessing using a noninvasive and nondestructive method. Equine SF metabolic profiles from both nonseptic joints (OA and OC) and septic joints were analyzed using 1D ¹H NMR spectroscopy. Univariate and multivariate statistical analyses were used to identify differential metabolite abundance between groups. Metabolites were annotated via ¹H NMR using 1D NMR identification software Chenomx,

SUBMITTER: Anderson JR 

PROVIDER: S-EPMC6092013 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature